TENGENA facilitates research and development into nanotechnologies by creating highly configurable plasma surface modification that advances different material properties. Our team empowers the state-of-the-art technology of controllable and precise plasma production applicable for the industrial pretreatment of components, surface activation, polymerization, and tissue healing. This low-pressure plasma discharge is generated by electromagnetic high-frequency fields between two electrodes in the closed chambers where gases or gas mixtures are ionized and converted into the highly reactive plasma state. The surface properties of inserted components are specifically changed by the choice of gas composition, such as the air, nitrogen, oxygen, and type of energy coupling.
The main developed system components of our plasma technology, nozzles, process controls, and generators, allow to fully exploit consistently high quality and reproducibility of plasma surface activation. As of today, the most efficient plasma pretreatment for cleaning, activating or coating plastics, metals, glass, recycled materials and composite materials have been employed under atmospheric pressure. Due to the unique feature, this type of plasma surface treatment is more economical and can be integrated directly into the existing production line, alternatively to low-pressure plasma and corona discharge. Atmospheric plasma is generated under normal pressure where the inserted components are treated over the large area and a waiting time is required before further processing. This makes the process very time-consuming, especially in the industrial treatment of substrates in larger quantities.
Whether attempting to improve adhesion of dissimilar materials, enhancing surface wettability or functional coating that repels biological fluids, plasma surface treatments add a significant value to biotechnology and many industrial applications. Our portfolio encompasses efforts along with an ever-growing list of applications that includes nanoelectronics, microscale plasmas devices, and energy generation and storage. Being concerned about the natural resources in the world, we think that our technologies have a green standing.
The development of specifically designed nanomaterials has significantly expanded into a broad range of biotechnological and pharmaceutical applications due to the overcoming limitations of free therapeutics and navigating systemic, microenvironmental, and cellular biological barriers. The NPs atomic structure promotes their physical, chemical, and biological applications due to their quantized electronic energy levels that are not continuous to corresponding bulk conformation. This quantum confinement phenomena determines nanomaterial properties, such as a size, surface area, and electron delimitation.
Overcoming functionalized interventions on an atomic, molecular, and supramolecular level directly affects the desired nanomaterials properties, including chemical reactivity, melting point, electrical conductivity, fluorescence, and magnetic permeability. The nanomaterials can improve the composite objects' overall performance by lending some of its unique properties when merged with or added to a pre-existing product. Otherwise, they can be used directly to create advanced and powerful devices attributed to their distinctive properties. The lipid-based, polymeric, and inorganic nanoparticles are engineered in increasingly specified ways to optimize the precise drug delivery platform in personalized manner of a precision medicine. In order to overcome heterogeneous barriers, recent NPs designs have utilized advancements in controlled synthesis strategies to incorporate complex architectures, bio-responsive moieties and targeting agents to finally enhance the delivery.
Therefore, these functionalized NPs can be utilized as more complex systems, particularly nanocarrier-mediated combination to alter multiple signal transduction pathways, maximize the therapeutic efficacy against specific macromolecules, target specific phases of the cell cycle, and overcome mechanisms of drug resistance. TENGENA aims to optimize our nanoproducts design to obtain a stable configuration and maximize the number of available functional groups and overcome the pitfalls of reducing nanoparticles stability.
Inorganic metal nanoparticles are commonly used in tissue engineering and biomedical applications due to their biocompatibility, low toxicity, and biodegradability. By manipulating materials and devices at the nanoscale, biomedical engineering creates structures with exceptional properties and functionalities that remain elusive in a vast spectrum of applications, such as controlled drug delivery, biomarker detection, colorimetric molecular sensors, targeted therapies, advanced imaging, biosensors and monitoring, and tissue engineering.
Nanotechnological materials have unique properties due to the surface-to-volume ratio of the structures, which increases the nutrition of cells, viability of regenerated tissues, and as three-dimensional matrices are suitable for cell growth and differentiation as well as the formation of new tissue. Specifically, nanofibers, nanoparticles, and nanocomposites can improve tissue adhesion and vascularization by mimicking the extracellular matrix, and development of artificial blood vessels.
The nanoparticles surface functionalization increases their specificity for targeted delivery systems to encapsulate drugs, vitamins, therapeutics, and enables specified delivery to cells or tissues without degradation, resulted in increased treatment efficacy and reduced side effects. Furthermore, the nanometric surface modifications improves biocompatibility of materials, stimulates cell adhesion, prevents bacterial colonization, and modulates immune responses. The application of these coatings significantly promotes the functionality and longevity of implants, ranging from orthopedic devices to cardiovascular stents, and dental implants.
TENGENA is currently undergoing rapid development of our nanoplatform in order to enhance potential applications in the field of nanoelectronics, catalysis, magnetic data storage, structural components, biomaterials, and biosensors. Using metal nanoparticles with the size of less 2 nm and nanometric materials, efficiently absorbed on nitrocellulose, our products can improve imaging methods’ sensitivity, resolution, and detectability, especially for magnetic resonance imaging, computed tomography, and fluorescence imaging, allowing for early disease detection, more accurate images, and the real-time monitoring of physiological parameters. As well as our cutting-edge production technology enables to improve the development of highly sensitive and specific nanosensors and nanoprobes to detect biomarkers, greatly expanding diagnostic possibilities.
From self-cleaning surfaces to ultra-strong fibers, our nanotechnology can help you to create new possibilities. TENGENA aims to equip manufacturers with control and repeatable surface engineering and modification processing over the low-pressure plasma etching technology and inorganic nanoparticles coating. Our team focuses on the development of non-corrosive oxygen plasma treatment for organic, inorganic, and polymeric materials. We empower the application of oxygen, argon, hydrogen plasma to process semiconductors in the etching devices, cleaning and activation of wafers and cell phone components, photoresist removal, oxide reduction of bond pads, and microfine cleaning of flexible electronics. Compare to chemical etching that uses hazard materials and most widely used radiofrequency (RF) and inductively coupled plasma (ICP), our plasma technology is safe, as well as effective due to the reactive species dissemination from plasma that are adsorbed on the surfaces of the materials/substrates.
On the other hand, it highlighted that unique chemicophysical traits of nanoparticles can directly contribute into enhanced functionalities and efficiency of semiconductors. In many processes involved in semiconductors production, copper, gold, and silver nanoparticles are essential, because they provide improved thermal stability, increased conductivity, and compatibility. The nanomaterials incorporation aids in the creation of high-performance hardware, and the execution of novel industrial fields, including environmental science, electronics, medicine, and energy.
Semiconductors are substances with characteristics halfway between conductivity and insulativity, which can be changed by doping them with impurities. In this case scenario, nanomaterials play a crucial role in enhancing semiconductors energy conversion and storage applications due to their unique surface area, efficient mass, heat, and charge transfer. In terms of energy applications, semiconductor nanoparticles have demonstrated promise in solar cells and harvesting industries. When it comes to quantum applications, semiconductor qubits are incredibly adaptable and cover a complete ecosystem, considering quantum simulation, sensing, computation, and communication. The stability and repeatability of semiconductor-based catalysts can be enabled by fusing two or more different types of nanomaterials with varying proportions of the components that continuously control the final product's properties.
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